[seventy eight] Thanks to their ubiquity, drugs that act on glutamate or GABA tend to get wide and potent effects. Some basic anesthetics act by minimizing the results of glutamate; most tranquilizers exert their sedative effects by enhancing the effects of GABA.[seventy nine]?? ????? ????? ??? ? ??? ?? ?? ???????? ???? ???? ????? ????? ?? ???? ???